Porcine Coronaviruses

Linda Saif Lab Publications --Porcine Coronaviruses

K. Jung,  G.J. Renukaradhya , K.P. Alekseev, Y. Fang, Y. Tang , L.J. Saif. 2009. Porcine reproductive and respiratory syndrome virus modifies innate immunity and alters disease outcome in pigs subsequently infected with porcine respiratory coronavirus: implications for respiratory viral co-infections. J Gen Virol. 90: 2713-23.

K. Jung, K.P. Alekseev, X. Zhang, D.S. Cheon, A.N. Vlasova, L. J. Saif. 2007.  Altered Pathogenesis of Porcine Respiratory Coronavirus in Pigs due to Immunosuppressive Effects of Dexamethasone: Implications for Corticosteroid Use in Treatment of Severe Acute Respiratory Syndrome Coronavirus. J of Virology. 81 (24): 13681–13693.

Costantini, V., P. Lewis, J. Alsop, C. Templeton and L.J. Saif. 2004. Respiratory and enteric shedding of porcine respiratory coronavirus (PRCV) in sentinel weaned pigs and sequence of the partial S gene of the PRCV isolates. Arch. Virol. 149:957-974.

Kim, L., K.O. Chang, K. Sestak, A. Parwani, and L.J. Saif. 2000. Development of a reverse transcription-nested polymerase chain reaction assay for differential diagnosis of transmissible gastroenteritis virus and porcine respiratory coronavirus from feces and nasal swabs of infected pigs. J Vet Diagn Invest 12:385-8.

Kim, L., J. Hayes, P. Lewis, A.V. Parwani, K.O. Chang, and L.J. Saif. 2000. Molecular characterization and pathogenesis of transmissible gastroenteritis coronavirus (TGEV) and porcine respiratory coronavirus (PRCV) field isolates co-circulating in a swine herd. Arch Virol 145:1133-47.

Sestak, K., R.K. Meister, J.R. Hayes, L. Kim, P.A. Lewis, G. Myers, and L.J. Saif. 1999. Active immunity and T-cell populations in pigs intraperitoneally inoculated with baculovirus-expressed transmissible gastroenteritis virus structural proteins. Vet Immunol Immunopathol 70:203-21.

Sestak, K., Z. Zhou, D.I. Shoup, and L.J. Saif. 1999. Evaluation of the baculovirus-expressed S glycoprotein of transmissible gastroenteritis virus (TGEV) as antigen in a competition ELISA to differentiate porcine respiratory coronavirus from TGEV antibodies in pigs. J Vet Diagn Invest 11:205-14.

Kwon, H.M., L.J. Saif, and D.J. Jackwood. 1998. Field isolates of transmissible gastroenteritis virus differ at the molecular level from the Miller and Purdue virulent and attenuated strains and from porcine respiratory coronaviruses. J Vet Med Sci 60:589-97.

Park, S., K. Sestak, D.C. Hodgins, D.I. Shoup, L.A. Ward, D.J. Jackwood, and L.J. Saif. 1998. Immune response of sows vaccinated with attenuated transmissible gastroenteritis virus (TGEV) and recombinant TGEV spike protein vaccines and protection of their suckling pigs against virulent TGEV challenge exposure. Am J Vet Res 59:1002-8.

Shoup, D.I., D.J. Jackwood, and L.J. Saif. 1997. Active and passive immune responses to transmissible gastroenteritis virus (TGEV) in swine inoculated with recombinant baculovirus-expressed TGEV spike glycoprotein vaccines. Am J Vet Res 58:242-50.

Saif, L.J. 1996. Mucosal immunity: an overview and studies of enteric and respiratory coronavirus infections in a swine model of enteric disease. Vet Immunol Immunopathol 54:163-9.

Sestak, K., I. Lanza, S.K. Park, P.A. Weilnau, and L.J. Saif. 1996. Contribution of passive immunity to porcine respiratory coronavirus to protection against transmissible gastroenteritis virus challenge exposure in suckling pigs. Am J Vet Res 57:664-71.

Shoup, D.I., D.E. Swayne, D.J. Jackwood, and L.J. Saif. 1996. Immunohistochemistry of transmissible gastroenteritis virus antigens in fixed paraffin-embedded tissues. J Vet Diagn Invest 8:161-7.

Brim, T.A., J.L. VanCott, J.K. Lunney, and L.J. Saif. 1995. Cellular immune responses of pigs after primary inoculation with porcine respiratory coronavirus or transmissible gastroenteritis virus and challenge with transmissible gastroenteritis virus. Vet Immunol Immunopathol 48:35-54.

Jackwood, D.J., H.M. Kwon, and L.J. Saif. 1995. Molecular differentiation of transmissible gastroenteritis virus and porcine respiratory coronavirus strains. Correlation with antigenicity and pathogenicity. Adv Exp Med Biol 380:35-41.

Lanza, I., D.I. Shoup, and L.J. Saif. 1995. Lactogenic immunity and milk antibody isotypes to transmissible gastroenteritis virus in sows exposed to porcine respiratory coronavirus during pregnancy. Am J Vet Res 56:739-48.

Brim, T.A., J.L. VanCott, J.K. Lunney, and L.J. Saif. 1994. Lymphocyte proliferation responses of pigs inoculated with transmissible gastroenteritis virus or porcine respiratory coronavirus. Am J Vet Res 55:494-501.

Saif, L.J., J.L. van Cott, and T.A. Brim. 1994. Immunity to transmissible gastroenteritis virus and porcine respiratory coronavirus infections in swine. Vet Immunol Immunopathol 43:89-97.

VanCott, J.L., T.A. Brim, J.K. Lunney, and L.J. Saif. 1994. Contribution of antibody-secreting cells induced in mucosal lymphoid tissues of pigs inoculated with respiratory or enteric strains of coronavirus to immunity against enteric coronavirus challenge. J Immunol 152:3980-90.

Jackwood, D.J., I. Bae, R.J. Jackwood, and L.J. Saif. 1993. Transmissible gastroenteritis virus and porcine respiratory coronavirus: molecular characterization of the S gene using cDNA probes and nucleotide sequence analysis. Adv Exp Med Biol 342:43-8.

Olsen, C.W., W.V. Corapi, R.H. Jacobson, R.A. Simkins, L.J. Saif, and F.W. Scott. 1993. Identification of antigenic sites mediating antibody-dependent enhancement of feline infectious peritonitis virus infectivity. J Gen Virol 74 ( Pt 4):745-9.

Saif, L.J. 1993. Coronavirus immunogens. Vet Microbiol 37:285-97.

Simkins, R.A., P.A. Weilnau, J. Van Cott, T.A. Brim, and L.J. Saif. 1993. Competition ELISA, using monoclonal antibodies to the transmissible gastroenteritis virus (TGEV) S protein, for serologic differentiation of pigs infected with TGEV or porcine respiratory coronavirus. Am J Vet Res 54:254-9.

VanCott, J.L., T.A. Brim, R.A. Simkins, and L.J. Saif. 1993. Isotype-specific antibody-secreting cells to transmissible gastroenteritis virus and porcine respiratory coronavirus in gut- and bronchus-associated lymphoid tissues of suckling pigs. J Immunol 150:3990-4000.

Simkins, R.A., P.A. Weilnau, J. Bias, and L.J. Saif. 1992. Antigenic variation among transmissible gastroenteritis virus (TGEV) and porcine respiratory coronavirus strains detected with monoclonal antibodies to the S protein of TGEV. Am J Vet Res 53:1253-8.

Bae, I., D.J. Jackwood, D.A. Benfield, L.J. Saif, R.D. Wesley, and H. Hill. 1991. Differentiation of transmissible gastroenteritis virus from porcine respiratory coronavirus and other antigenically related coronaviruses by using cDNA probes specific for the 5' region of the S glycoprotein gene. J Clin Microbiol 29:215-8.

Benfield, D.A., D.J. Jackwood, I. Bac, L.J. Saif, and R.D. Wesley. 1991. Detection of transmissible gastroenteritis virus using cDNA probes. Arch Virol 116:91-106.

Simkins, R.A., L.J. Saif, and P.A. Weilnau. 1989. Epitope mapping and the detection of transmissible gastroenteritis viral proteins in cell culture using biotinylated monoclonal antibodies in a fixed-cell ELISA. Arch Virol 107:179-90.

Welch, S.K. and L.J. Saif. 1988. Monoclonal antibodies to a virulent strain of transmissible gastroenteritis virus: comparison of reactivity with virulent and attenuated virus. Arch Virol 101:221-35.

Welch, S.K., L.J. Saif, and S. Ram. 1988. Cell-mediated immune responses of suckling pigs inoculated with attenuated or virulent transmissible gastroenteritis virus. Am J Vet Res 49:1228-34.

Saif, L. J. 1985. Passive immunity to coronavirus and rotavirus infections in swine and cattle: enhancement by maternal vaccination. Infect. Diarrhea in the Young. S. Tzipori, Ed, Elseiver, The Netherlands, pp. 456‑467.

Saif, L.J. and E.H. Bohl. 1983. Passive immunity to transmissible gastroenteritis virus: intramammary viral inoculation of sows. Ann N Y Acad Sci 409:708-23.

Theil, K.W., L.J. Saif, E.H. Bohl, A.G. Agnes, and E.M. Kohler. 1979. Concurrent porcine rotaviral and transmissible gastroenteritis viral infections in a three-day-old conventional pig. Am J Vet Res 40:719-21.

Saif, L.J. and E.H. Bohl. 1979. Passive immunity in transmissible gastroenteritis of swine: immunoglobulin classes of milk antibodies after oral-intranasal inoculation of sows with a live low cell culture-passaged virus. Am J Vet Res 40:115-7.

Saif, L.F. and E.H. Bohl. 1977. Immunoglobulin classes of antibodies in milk of swine after intranasal exposure to pseudorabies virus or transmissible gastroenteritis virus. Infect Immun 16:961-6.

Saif, L.J., E.H. Bohl, E.M. Kohler, and J.H. Hughes. 1977. Immune electron microscopy of transmissible gastroenteritis virus and rotavirus (reovirus-like agent) of swine. Am J Vet Res 38:13-20.

Bohl, E.H. and L.J. Saif. 1975. Passive immunity in transmissible gastroenteritis of swine: immunoglobulin characteristics of antibodies in milk after inoculating virus by different routes. Infect Immun 11:23-32.

Bohl, E.H., T. Frederick, and L.J. Saif. 1975. Passive immunity in transmissible gastroenteritis of swine: intramuscular injection of pregnant swine with a modified live-virus vaccine. Am J Vet Res 36:267-71.

Bohl, E.H., L.J. Saif, R.K. Gupta, and G.T. Frederick. 1974. Secretory antibodies in milk of swine against transmissible gastroenteritis virus. Adv Exp Med Biol 45:337-42.

Bohl, E.H., R.K. Gupta, L.W. McCloskey, and L. Saif. 1972. Immunology of transmissible gastroenteritis. J Am Vet Med Assoc 160:543-9.

Bohl, E.H., R.K. Gupta, M.V. Olquin, and L.J. Saif. 1972. Antibody responses in serum, colostrum, and milk of swine after infection or vaccination with transmissible gastroenteritis virus. Infect Immun 6:289-301.

Saif, L.J., E.H. Bohl, and R.K. Gupta. 1972. Isolation of porcine immunoglobulins and determination of the immunoglobulin classes of transmissible gastroenteritis viral antibodies. Infect Immun 6:600-9.